It is well known that variation in quality is observed for different brands of dosage form as well as in the same brand between different batches. Therefore it was thought of interest to study the quality of marketed formulations. To determine the quality of the dosage form various quality parameters are to be evaluated. In the present work quality parameters, assay and dissolution profile are evaluated to assure quality of dosage form. Several methods such as UV spectroscopy and HPLC have been reported in literature for estimation of the test drug samples in the combined tablet dosage form. Most of the work emphasizes on HPLC. HPLC though accurate and precise method, is time consuming and costly and requires skilled operator.Therefore, it was thought of interest to develop a simple, economical, precise and accurate Simultaneous equation method for simultaneous estimation of Test sample drugs. This will give upcoming analytical students to work on such areas of analytical method development validation aspects.
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Medicine and the Bomb by Paul Langley
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